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. 2022 Dec 15;191(2):321–331. doi: 10.1093/toxsci/kfac132

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Increased sensitivity of Ahr^dbd/dbd mice to DSS-induced colitis. A, Disease index score (DAI) was assessed daily in all groups. Parameters measured were blood in stool, diarrhea, rectal bleeding, and rectal prolapse. *p < .05 2-way ANOVA compared with genotype-matched and no DSS treated mice. ^#p < .05 2-way ANOVA compared with day-matched and DSS treated mice. B, Colon length and (C) spleen wet weight corrected for body weight were assessed upon dissection. *p < .05 2-way ANOVA compared with genotype-matched and no DSS-treated mice. ^#p < .05 2-way ANOVA compared with genotype-matched and DSS-treated mice (D) H&E stain of colon tissue in healthy control mice and mice treated with 2% DSS. Ahr^dbd/dbd mice exhibit extensive tissue damage and immune cell infiltration compared with Ahr^+/+ mice. The arrows indicate infiltration of inflammatory cells and crypt loss. Abbreviation: DSS, dextran sulfate sodium.