Figure 3.

Transcription factor binding motif enrichment in Mtb-infected macrophages. TF binding motifs across all genotypes that were significantly enriched in ATAC-seq peaks with increased or decreased chromatin accessibility were identified; those with enrichment score >2.5 and FDR < 0.001 were considered significant. (A) Enrichment and significance of the selected motifs in DAR with increased chromatin accessibility. Grey dots indicate the percentage of regions that have at least one hit to the motif. Bright red indicates motifs that are statistically significant. (B) Enrichment for the same motifs as shown in panel A, but within DAR with decreased chromatin accessibility following Mtb infection. Bright blue indicates motifs that are statistically significant.