Study	Observations on resources needed to deliver the intervention
Bertelsen 2008	Significant additional resource required to deliver intervention.
Bruzzese 2006	Substantial support needed to deliver the intervention.
Challis 2002	Mean costs per annum: £23,402 for intervention group, £19,053 for control group. Additional resources required could account for any benefits achieved.
Cooper 1975	Additional resources in intervention group included a social worker allocated to GP practice and involvement of two research team psychiatrists.
Coppins 2011 NEW	Cost per child was estimated at £403 compared with £45 for usual care of 1.5 hours of individual dietetic consultations.
Florence 2011 NEW	Additional resource was a data analyst to combine health and police data.
Hultberg 2005	The total healthcare cost for an average patient in the intervention was EUR 1979 and EUR 1286 for controls.
Kloek 2006	Expensive programme to implement and additional service could explain any improvements rather than the collaboration itself.
Lumley 2006	Additional resource requirements included employment and training of community development officers and the production and distribution of information packs.
Melle 2008	Additional resources would be required to replicate this service. (USD 390 for awareness raising strategies ‐ unclear whether this is per patient)
Rosen 2006 NEW	Additional resources included medical and epidemiological lectures given to the teachers, environmental equipment for the preschools, educational resource packs and puppet theatre visits. For the home intervention there were information packages. Teachers needed to spend time reinforcing hand hygiene messages with the children in class.
Smylie 2008 NEW	The routine sex education curriculum was usually delivered by physical education teachers and varied in time spent and style of delivery. The intervention programme was highly structured and included several specialists: sexual health worker, social worker from a sexual assault crisis centre, public health nurse. Plus a newsletter and several three‐hour parent workshops.
Tucker 2006	Exact costs unclear though additional costs incurred for training and new drop‐in centres.
Vickrey 2006	Significant extra resources appeared to be used in the intervention group, although it is unclear what costs were associated with this.
Woodfine 2011 NEW	Significant additional resource required. Cost effectiveness of intervention: Shift from ‘severe’ to ‘moderate’ asthma: I = 17%; C =3%. Mean cost of modifications: £1718 per child treated or £12,300 per child shifted from ‘severe’ to ‘moderate’. No significant difference in healthcare costs over 12 months between groups.  ‘Bootstrapping’ gave an incremental cost‐effectiveness ratio (ICER) of £234 per point improvement on the 100‐point PedsQL™ asthma‐specific scale (95% CI £140 to £590). ICER fell to £165 (95% CI £84 to £424) for children with ‘severe’ asthma.
Young 2005	Appears to be reorganisation of existing resource rather than utilising additional resources.