Table 2.
Deletion of hepatocyte Tfrc in Hfe knockout mice does not change red blood cell parameters compared with Hfe single knockout mice
| Sex | Diet | Genotype | HCT (%) | Hgb (g/dL) | MCV (fL) | MCH (pg) | RDW (%) |
|---|---|---|---|---|---|---|---|
| Male | Con | Hfe−/−;Tfrcfl/fl;Alb-Cre− | 41.7 ± 0.6 | 13.5 ± 0.2 | 49.4 ± 0.3 | 15.9 ± 0.1 | 15.9 ± 0.1 |
| Hfe−/−;Tfrcfl/fl;Alb-Cre+ | 41.0 ± 0.7 | 13.4 ± 0.2 | 49.2 ± 0.3 | 16.1 ± 0.1 | 15.8 ± 0.1 | ||
| Low Fe | Hfe−/−;Tfrcfl/fl;Alb-Cre− | 42.4 ± 1.5 | 13.7 ± 0.4 | 49.0 ± 0.3 | 15.9 ± 0.1 | 16.1 ± 0.1 | |
| Hfe−/−;Tfrcfl/fl;Alb-Cre+ | 40.7 ± 1.4 | 13.1 ± 0.5 | 48.1 ± 0.5 | 15.4 ± 0.3 | 17.2 ± 0.5 | ||
| Female | Con | Hfe−/−;Tfrcfl/fl;Alb-Cre− | 40.3 ± 0.5 | 13.1 ± 0.1 | 49.1 ± 0.3 | 16.0 ± 0.2 | 15.7 ± 0.2 |
| Hfe−/−;Tfrcfl/fl;Alb-Cre+ | 41.3 ± 0.9 | 13.6 ± 0.3 | 49.8 ± 0.3 | 16.4 ± 0.1 | 15.8 ± 0.1 | ||
| Low Fe | Hfe−/−;Tfrcfl/fl;Alb-Cre− | 43.9 ± 1.1 | 14.1 ± 0.3 | 49.5 ± 0.3 | 15.9 ± 0.2 | 16.2 ± 0.1 | |
| Hfe−/−;Tfrcfl/fl;Alb-Cre+ | 42.3 ± 1.2 | 13.5 ± 0.5 | 47.8 ± 1.1 | 15.3 ± 0.5 | 17.9 ± 1.3 |
Data represent means ± SEM; n = 3 to 10 mice per group (7 weeks old). No significant differences were observed between sex- and diet-matched genotypes by the Student t test.
Abbreviations are explained in Table 1.