Fig. 1. Screen for genetic factors controlling transcriptional memory.

A Heatmap depicting strain-specific z-cores for pGAL1-sGFP expression at different time points. Green refers to high sfGFP expression (see Supplementary Data 1 and methods for detail). B Top 19 candidate deletion strains displaying enhanced transcriptional memory. Lines represent known interactions as curated by STRING v11.5⁴⁸.blue indicate from curated databases, pink indicate experimentally determined, green indicate predicted interaction as gene neighborhood, light green indicate source as text mining, black indicate co-expression. C Relative sfGFP expression for components of the nuclear exosome in red line (rrp6∆) relative to wild type in black line (y-axis from 1 (all cells with no detectable GFP) to 4 (all cells with maximum GFP), see Methods for detail).