Fig. 17.

a The results of an AMD simulation showing the creation of a cluster of five bexarotene molecules inside the core of phospholipid-based sterically stabilized micelles core after 11 ns of equilibration. The zoomed-in figure details a chain of hydrogen bonds between the COOH groups. b Two networks of hydrogen bonds are formed in the cluster of 11 bexarotene molecules in the sterically stabilized micelles core After 17 ns of equilibration. c The nonpolar component of a solvated bexarotene molecule is directed toward the alkane core, while the COOH group is orientated toward the ionic interface. Reprinted from [297], Copyright 2013 American Chemical Society