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. 2023 Feb 3;14:1060540. doi: 10.3389/fimmu.2023.1060540

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Copyright © 2023 Clubb, Kudling, Girych, Haybout, Pakola, Hamdan, Cervera-Carrascon, Hemmes, Grönberg-Vähä-Koskela, Santos, Quixabeira, Basnet, Heiniö, Arias, Jirovec, Kaptan, Havunen, Sorsa, Erikat, Schwartz, Anttila, Aro, Viitala, Vattulainen, Cerullo, Kanerva and Hemminki

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Cross-reactivity of 11B12-1 and 12F1-1 with human samples. (A) Evaluating cross reactivity of 11B12-1 and 12F1-1 with four human cancer cell lines (A549, HSC-3, Ovarian PDX and Panc 1), human PBMCs and hamster cancer cell like (HaptT1) by flow cytometry. Percentage of FITC⁺ was used as a readout and each stain compared with respective isotype control. (B) Immunohistochemistry staining of patient head and neck squamous cell carcinoma tumour (HUSHN) with 11B12-1, 12F1-1 and anti-human PD-L1 mAb (PD-L1 [E1L3N^®] XP^® Rabbit mAb). Statistical significance of flow cytometry data was evaluated using an unpaired t-test with Welch’s correction. *p < 0.05; ns, not significant. Error bars are presented as mean ± SEM.