Figure 4 |.

Optimization of allopregnanolone treatment regimens for regeneration and repair. The processes of renewal and repair require time and occur in stages in an obligatory sequence. Neurogenesis occurs over the course of hours, in the case of transitioning through the cell cycle, to months in the case of full integration into hippocampal circuitry and networks. Activating both regenerative and repair systems to maximize therapeutic benefit in the ageing or degenerating brain requires simultaneous assessment of both processes and investigation of multiple dosing and regimes to arrive at an optimal course of therapy. In the case of APα, a once per week treatment regimen with a single dose of APα (10 mg/kg) was optimal to promote neurogenesis while also activating systems that reduced Alzheimer disease pathology.³⁵ By contrast, constant infusion treatment regimens over the course of months are antiregenerative and result in adverse outcomes.⁵⁷ Abbreviation: APα, allopregnanolone.