Table 2.
Enrichment analysis of genes that are associated with XFS
| Tool | Database | enrichment | Name | # found | # total | Adj-p-values/FDR |
|---|---|---|---|---|---|---|
| Reactome | reactome | pathway | Endosomal/Vacuolar pathway | 59 | 82 | 1.83E-07 |
| GSEA | reactome | pathway | Crosslinking of collagen fibrils | 5 | 8 | 0.031 |
| Enrichr | Jensen Diseases | Disease | Rheumatoid_arthritis | 119 | 310 | 8.32E-08 |
| Type_1_diabetes_mellitus | 68 | 158 | .69E-06 | |||
| Carcinoma | 2619 | 11,318 | 0.013 | |||
| Vitiligo | 28 | 63 | 0.029 | |||
| Enrichr | GWAS Catalog | traits | Caffeine consumption | 11 | 14 | 0.019 |
| Enrichr | DSigDB | Drugs | cyclosporin A_CTD_00007121 | 1258 | 4826 | 9.66E-11 |
| VALPROIC ACID_CTD_00006977 | 2041 | 8313 | 1.75E-09 | |||
| Copper sulfate_CTD_00007279 | 1508 | 6017 | 3.04E-08 | |||
| quercetin_CTD_00006679 | 812 | 3159 | 7.82E-05 | |||
| acetaminophen_CTD_00005295 | 1017 | 4136 | 0.007 | |||
| AFLATOXIN B1_CTD_00007128 | 773 | 3082 | 0.006 | |||
| (−)-Epigallocatechin gallate_CTD_00002033 | 546 | 2115 | 0.005 | |||
| POTASSIUM CHROMATE_CTD_00001284 | 491 | 1898 | 0.011 | |||
| METHAMPHETAMINE_CTD_00006286 | 40 | 102 | 0.030 | |||
| METHYL METHANESULFONATE_CTD_00006307 | 940 | 3685 | 0.047 |