TABLE 3. Liver parameters at 2 years of age in each bile acid group.

Two‐year liver parameter	Value, median (range) [n]	Estimate > 40 vs. ≤40 μmol/L (95% CI)	p	R 2
Total bilirubin (mg/dl)
≤40 μmol/L group	0.3 (0.1, 0.8) [30]	2.1‐fold (1.6, 2.8)	<0.001	0.22
>40 μmol/L group	0.6 (0.2, 6.0) [66]
AST (U/L)
≤40 μmol/L group	58 (28, 218) [34]	1.8‐fold (1.4, 2.3)	<0.001	0.18
>40 μmol/L group	106 (40, 860) [72]
ALT (U/L)
≤40 μmol/L group	45 (8, 392) [34]	1.9‐fold (1.4, 2.6)	<0.001	0.13
>40 μmol/L group	114 (17, 828) [72]
GGT (U/L)
≤40 μmol/L group	44 (7, 331) [29]	3.7‐fold (2.3, 5.9)	<0.001	0.26
>40 μmol/L group	187 (17, 2608) [57]
Albumin (g/dl)
≤40 μmol/L group	4.4 (3.6, 5.0) [34]	−0.3 (−0.5, −0.2)	<0.001	0.14
>40 μmol/L group	4.1 (3.0, 5.0) [71]
INR
≤40 μmol/L group	1.0 (0.9, 1.2) [31]	0.009 (−0.038, 0.057)	0.704	0.00
>40 μmol/L group	1.0 (0.8, 1.6) [62]
Total bile acids (μmol/L)
≤40 μmol/L group	12 (5, 44) [14]	4.9‐fold (2.8, 8.7)	<0.001	0.47
>40 μmol/L group	59 (9, 330) [21]
Spleen size (cm below costal margin)
≤40 μmol/L group	0.0 (0.0, 7.0) [32]	2.2 (1.2, 3.2)	<0.001	0.16
>40 μmol/L group	3.0 (0.0, 10.0) [69]
Platelet count (109/L)
≤40 μmol/L group	275 (107, 440) [31]	0.7‐fold (0.6, 0.9)	<0.001	0.11
>40 μmol/L group	178 (68, 579) [69]
Weight z score
≤40 μmol/L group	−0.06 (−2.86, 2.36) [35]	0.047 (−0.418, 0.513)	0.843	0.00
>40 μmol/L group	0.16 (−3.04, 2.13) [75]
Height z score
≤40 μmol/L group	−0.24 (−4.29, 2.22) [34]	0.002 (−0.466, 0.470)	0.994	0.00
>40 μmol/L group	−0.48 (−3.25, 2.45) [76]
25‐OH vitamin D (ng/ml)
≤40 μmol/L group	37.0 (16.0, 62.3) [21]	3.7 (−5.4, 12.8)	0.433	0.01
>40 μmol/L group	38.0 (3.2, 110.0) [41]

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma‐glutamyltransferase; INR, internationalized normal ratio; OH, hydroxy.