TABLE 5. Summary of bile acid profiles in each bile acid group.
| Bile acid species | Six‐month post‐KP bile acid group | p | ||
|---|---|---|---|---|
| ≤40 μmol/L (n = 43) | >40 μmol/L (n = 94) | |||
| Total (μmol/L), median (range) [n] | 27 (2, 39) [43] | 107 (42, 322) [94] | <0.001 | |
| Unconjugated (μmol/L), median (range) [n] | ||||
| CA | 0.1 (0.0, 1.7) [43] | 0.1 (0.0, 1.5) [94] | 0.242 | |
| CDCA | 0.3 (0.0, 1.4) [43] | 0.2 (0.0, 3.3) [94] | 0.170 | |
| UDCA | 2.3 (0.0, 11.0) [25] | 2.6 (0.0, 25.7) [58] | 0.695 | |
| Conjugated (μmol/L), median (range) [n] | ||||
| CA | 3.5 (0.5, 30.1) [43] | 45.3 (4.4, 353.6) [94] | <0.001 | |
| CDCA | 7.2 (2.3, 27.8) [43] | 39.9 (8.7, 168.5) [94] | <0.001 | |
| UDCA | 6.9 (0.5, 26.5) [25] | 28.0 (0.0, 208.3) [58] | <0.001 | |
| Ratio of taurine/glycine‐conjugated, median (range) [n] | ||||
| CA | 0.7 (0.2, 2.9) [43] | 1.0 (0.1, 5.7) [94] | 0.003 | |
| CDCA | 0.7 (0.1, 3.3) [43] | 1.0 (0.2, 5.6) [94] | <0.001 | |
| UDCA | 0.1 (0.0, 0.9) [25] | 0.2 (0.1, 1.4) [57a] | 0.006 | |
Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; GUDCA, glycoursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid.
a
One participant had TUDCA and GUDCA concentrations that were below detection, so a ratio was not calculated.