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. 2023 Feb 17;77(3):1036–1065. doi: 10.1002/hep.32689

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of American Association for the Study of Liver Diseases.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/

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Proposed diagnostic algorithm for patients with suspected DILI. A diagnosis of DILI relies on careful elicitation of clinical history and drug exposures along with exclusion of other more common causes of liver injury. Abbreviations: A1AT, alpha‐1‐antitrypsin; ALP, alkaline phosphatase; ALT alanine aminotransferase; AMA, anti‐mitochondrial antibody; ANA, antinuclear antibody; APAP, acetaminophen; ASMA, anti‐smooth muscle antibody; AST, aspartate aminotransferase; CK, creatine kinase; CMV, cytomegalovirus; EBV, Epstein–Barr virus; HDS, herbal and dietary supplement; HSV, herpes simplex virus; INR, international normalized ratio; LDH, lactate dehydrogenase; T3, triiodothyronine; T4, thyroxine; TB, total bilirubin; TSH, thyroid stimulating hormone; TTG, tissue transglutaminase; ULN, upper limit of normal.