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. 2023 Feb 17;77(3):1036–1065. doi: 10.1002/hep.32689

TABLE 7. HDS products and ingredients implicated in hepatotoxicity.

Ingredient Chemical structure Common uses Hepatotoxicity phenotype Expected outcome
Ashwagandha,135 Withania somnifera Steroidal lactone Neuroprotection, anti‐inflammatory Cholestatic or mixed Recovery expected
Green tea extract72,132 Catechin‐polyphenol Weight loss Hepatocellular Most recover; liver failure, transplant, death reported
Garcinia cambogia136 (−)‐hydroxycitric acid Weight loss Hepatocellular
Polygonum multiflorum 73,137 Stilbenes and anthraquinones Anti‐aging, intestinal function Hepatocellular or mixed Most recover; fatalities reported
Chinese skullcap, Scutellaria baicalensis; Scutellaria lateriflora Flavonoid Anxiety, insomnia, neurological disorders Hepatocellular Recovery typical
Kratom,138 Mitragyna speciosa Tetracyclic indole and pentacyclic oxindole alkaloids Anxiety, opiate effect, or withdrawal Mixed Recovery typical
Anabolic steroids139 Steroid backbone Bodybuilding, performance enhancement Cholestasis Prolonged jaundice, full recovery
Turmeric/curcumin140142 Polyphenol Anti‐inflammatory, weight loss, anticancer, cardiovascular disease Hepatocellular Recovery expected; one case of AIH reported