. 2023 Feb 17;77(3):1036–1065. doi: 10.1002/hep.32689

TABLE 8. Prognostic indices for patients with idiosyncratic DILI.

Model/parameter	Model components	Proposed thresholds for liver transplant/death	Comments
MELD score143	Bilirubin, INR, and creatinine	AUROC = 0.83	Developed for cirrhosis patients
Hy's law145	ALT > 3× ULN and bilirubin > 2.5 mg/dl	PPV = 8%–20%	ALP should be < 2× ULN; not applicable to mixed/cholestatic cases
Modified Hy's law144	R‐value > 5 and bilirubin > 2.5 mg/dl	PPV = 12%; AUROC = 0.73
Charlson Comorbidity Index and labs146 ^a	MELD score, albumin, Charlson > 2	AUROC = 0.89	Discovery and validation cohort used for 6‐month mortality

Abbreviations: AUROC, area under the receive operating curve; MELD, Model for End‐Stage Liver Disease; PPV, positive predictive value.

^{^a}