FIG 10.

Lower circIFNGR2 partially reversed the inhibition of OVCA by exosomes derived from CAFs in vitro. (A) Relative expression levels of circIFNGR2 in OVCA cells transfected with si-circIFNGR2 #1 and #2 plasmids were examined by qRT-PCR. A2780 and OV90 cells were transfected with si-NC or si-circIFNGR2, and then co-cultured with CAF-exo. (B) Cell colony formation ability was examined by colony formation assay. (C and D) Transwell assay was constructed to assess OVCA cells migration and invasion abilities. (E and F) The mRNAs levels of E-cadherin (E), N-cadherin (F) and vimentin (F) were assessed by qRT-PCR. (G) E-cadherin, vimentin and N-cadherin proteins were verified by Western blotting in each experimental group. Standardized to GAPDH. **P < 0.01, ***P < 0.05 and †P < 0.01.