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. 2023 Jan 31;40(2):msad022. doi: 10.1093/molbev/msad022

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© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Promoter CpG islands DNA methylation profiling for Smc6l, Npdc1-Pou5f3, Nkrfl2, Zfp68, and Rwdd2a. (A) Npdc1 promoter DNA methylation in fetal brain determined by cloning and Sanger sequencing after bisulfite treatment. The parental transmission direction was inferred from an information SNP between LL1 and LL2 strains in the amplified region. The solid and open circles represent methylated and unmethylated CpG sites, respectively. (B) Promoter DNA methylation profile for X-linked Smc6l in the fetal brain. (C) Left: gene regions of five confirmed imprinted genes with the maternal alleles in red and paternal alleles in blue. Right: programs and DNA methylation percentages at promoter CpGs quantified by PyroMark assays.