Figure 5.
(A) Human BCL2 gene promoter. (B) BCL2 promoter G-quadruplex forming sequences for P1G4 and Pu39 regions. (C) (left) Two equilibrating parallel G-quadruplexes formed in Bcl2-P1G4 with a unique hairpin structure. (right) Two distinct interchangeable three-tetrad G-quadruplexes formed in Bcl2-Pu39. Bcl2-Mid adopts a hybrid-2 structure, while Bcl2-1245 adopts a parallel structure. Loop arrangements are shown in parentheses.