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. 2023 Feb 15;10(2):ENEURO.0361-22.2023. doi: 10.1523/ENEURO.0361-22.2023

Figure 3.

Figure 3.

Dopamine release and uptake in the NAc core of Long photoperiod female mice are more sensitive to DAT inhibition by GBR 12783. A, Representative traces of evoked NAc core dopamine release across increasing concentrations of GBR 12783 in Short (males N = 4, females N = 4), Equinox (males N = 4, females N = 5), and Long (males N = 5, females N = 6) photoperiod female mice. Dotted lines denote magnitude of release in control aCSF condition. B, Evoked NAc core dopamine release with increasing concentrations of GBR 12783 had a main effect of photoperiod in females (F(2,44) = 3.351, p = 0.0442). C, Magnitude of uptake inhibition (apparent Km) showed a main effect of photoperiod (F(2,48) = 16.21, p < 0.0001), GBR 12783 dose (F(3,48) = 12.27, p < 0.0001), and an interaction effect (F(6,48) = 4.585, p = 0.0009). D, Representative traces of evoked NAc core dopamine release across increasing concentrations of GBR12783 in Short, Equinox, and Long photoperiod male mice. Dotted lines denote magnitude of release in control aCSF condition. Evoked NAc dopamine release (E) and magnitude (F) of uptake inhibition with increasing concentrations of GBR 12783 in male mice. *p < 0.05, ****p < 0.0001 for Long versus Equinox; #p < 0.05, ####p < 0.0001 for Long versus Short. Data were analyzed using two-way ANOVA and Tukey’s post hoc multiple comparisons test with an α value of p = 0.05. Data are represented as mean ± SEM.