Table 4.

Patents granted in 2012–2022 in relation to chitosan-based drug delivery system for the treatment of AD

No.	Patent no.	Year	Patent title	Inventor(s)	Formulation type	Reference
1	EP 1889608 B1	2012	Therapeutic hydrogel for atopic dermatitis and preparation method	Nho et al.	Gel	[90]
2	US 8324356 B2	2012	Polysaccharide derivatives of lipoic acid, and their preparation and use as skin cosmetics and devices	Fabrizio et al.	Cream	[96]
3	US 8636982 B2	2014	Wax foamable vehicle and pharmaceutical compositions	Dov et al.	Foam	[93]
4	MY 169467 A	2019	Chitosan-based skin targeted nanoparticle drug delivery system	Haliza and Shariza	Nanoparticles	[91]
5	US 10111835 B2	2018	Microparticles for encapsulating probiotics, production and uses	Maite et al.	Microparticles	[92]
6	US 10201490 B2	2019	Use of chitosans for the treatment of nail inflammatory diseases	Federico	Nail Lacquer	[94]
7	US 10226483 B2	2019	Topical compositions and methods of using the same	Ryan and Jian	Gel	[95]
8	US 10443033 B2	2019	Lactobacillus rhamnosus RHT-3201 conjugated to polysaccharide polymer binder for prevention or treatment of atopic diseases	Lee et al.	Gel	[98]
9	EP 3429691 B1	2020	Non-aqueous Topical Compositions comprising a halogenated salicylanilide	Alexander et al.	Gel	[100]
10	EP 2968209 B1	2020	Metadichol R liquid and gel nanoparticle formulations	Palayakotai et al.	Nanoparticles	[99]
11	EP 3429600 B1	2021	New Immunobiological products	Igor and Liudmila	Hydrocolloid	[97]