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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Mod Pathol. 2023 Jan;36(1):100034. doi: 10.1016/j.modpat.2022.100034

Figure 5: Associations between hypoxic response gene signature and VEGFA expression.

Figure 5:

(A-C) Box plots showing the “Cellular Response to Hypoxia” gene set enrichment score in VEGFA-Low and VEGFA-Med/High ROIs in specimens (A) HGG03, (B) HGG05, and (C) HGG06. P-values were calculated using an unpaired t-test with Welch’s correction where p < 0.05 is considered statistically significant. (D-F) Spearman correlation matrix showing the relationships between genes encoding pro-angiogenic molecules and the “Cellular Response to Hypoxia” gene set enrichment score in VEGFA -Low and VEGFA -Med/High ROIs in specimens (D) HGG03, (E) HGG05, and (F) HGG06. Circle size indicates p value where circles with inlaid black squares indicating failure to reach statistical significance (p<0.05). Color bar indicates Spearman’s rho.