Figure 5. STRING diagrams illustrate functional categories of release site proteins and their disruption in RIM cKO^DA mice.

(A) STRING diagram of the enriched proteins that have a synaptic SynGO annotation in the control dataset. Physical or functional interactions determined by either empirical data or predictive modeling are illustrated as lines between proteins (Snel et al., 2000; Szklarczyk et al., 2019). The BirA bait proteins are color-coded. Functional categories identified by STRING analyses are labeled close to the corresponding clusters. (B) Same as (A), but for the RIM cKO^DA dataset. The proteins that are enriched only in the RIM^PPCP-BirA bait are shown in lighter gray. (C) Same as (A), but for the Syt-1 cKO^DA dataset. Number of proteins: (A) 194; (B) 79; (C) 163.