Table I.
Correlations between the expression of CBXs, clinical characteristics and cancer prognosis.
| Cancer type | Expression
|
Clinical characteristics
|
Prognosis
|
Research methods | (Refs.) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ↑ | ↓ | Tumorsize ↑ | Grade ↑ | Stage↑ | Metastasis ↑ | Relapse ↑ | Others | OS ↓ | Others | |||
| Glioma | CBX2/3/5/8 | CBX6/7 | CBX2/3/8↑ | CBX2/3/8↑ | CBX3/8↑ CBX6↓ | BI | (67) | |||||
| Glioma | CBX2/3/5/8 | CBX6/7 | CBX2/6/7↑: IDH mutation↑ | CBX7↓ CBX8↑ | BI | (68) | ||||||
| Glioma | CBX3 | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑: RFS↓ | BI; WB; qPCR | (69) | ||||
| TSCC | CBX3 | CBX3↑ | CBX3↑ | CBX3↑ | IHC; WB; qPCR | (70) | ||||||
| HNSCC | CBX1/2/3/4/5/6/8 | CBX7 | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑: vascular invasion↑ | CBX3↑ CBX5↓ | BI; qPCR | (71) | |||
| BC | CBX2 | CBX2↑ | CBX2↑ | CBX2↑: DFS↓ | BI | (72) | ||||||
| BC | CBX2 | CBX2↑ | CBX2↑: PFS↓ | BI; IHC | (73) | |||||||
| BC | CBX2 | CBX2↑ | CBX2↑ | CBX2↑ | CBX2↑: HER-2 positive state↑ | CBX2↑ | IHC | (74) | ||||
| BC | CBX2 | CBX2↑ | BI | (75) | ||||||||
| BC | CBX4 | CBX4↑ | CBX4↑ | CBX4↑ | IHC; WB; qPCR | (76) | ||||||
| BC | CBX1/2/3/5/8 | CBX6/7 | CBX2↑ CBX4/6/7↓ | CBX1/7/8↑: PPS↑ CBX1/2/3/5↑ CBX6/7↓: DMFS↓ | BI; IHC | (77) | ||||||
| BC | CBX2/3/4/7/8 | CBX1/2/3↑ CBX4/5/6/7↓: RFS↓ | BI | (78) | ||||||||
| BC | CBX2 | CBX7 | CBX2↑ CBX7↓ | BI | (15) | |||||||
| BC | CBX8 | CBX8↑ | BI | (79) | ||||||||
| BC | CBX2/3/4/8 | CBX6/7 | CBX3↑ | CBX3/5↑ CBX4↓ | CBX3↑: DFS↓ | BI | (80) | |||||
| NSCLC | LUAD: CBX1/2/3/4/5/8↑ LUSC: CBX1/2/3/4/5↑ | CBX6/7 (LUAD); CBX7/8 (LUSC) | CBX3↑ | CBX1/3 (LUAD)↑ | CBX1/3 (LUAD)↑: DSS↓ DFS↓ PFS↓ | BI | (81) | |||||
| NSCLC | CBX3 | CBX3↑: EGFR mutation↑ | BI; IHC | (82) | ||||||||
| NSCLC | CBX7 | CBX7 (LUAD)↓ | BI | (83) | ||||||||
| LUAD | CBX1/2/3/5 | CBX7 | CBX3/5↑ CBX7↓ | CBX3/5↑ CBX7↓ | CBX1/3/5↑ CBX7/8↓ | BI | (84) | |||||
| LUAD | CBX7 | CBX7↓ | BI; IHC | (125) | ||||||||
| LUAD | CBX4 | CBX4↑ | BI; IHC | (85) | ||||||||
| EC | CBX1/2/3/4/5/8 | CBX1↑ | CBX3/4/8↑ CBX7↓ | CBX1↑: DFS↓ | BI | (86) | ||||||
| EC | CBX1/3/8 | CBX7 | CBX3/4↑ CBX7↓ | CBX1↑: PFS↓ CBX4/5↑: DFS↓ | BI | (87) | ||||||
| EC | CBX3/4/5/8 | CBX7 | CBX3/4/7/8↑ | BI | (88) | |||||||
| EC | CBX2 | CBX2 | ↑ | CBX2↑: DSS↓ | IHC; qPCR | (89) | ||||||
| EC | CBX8 | CBX8↑ | IHC; WB; qPCR | (90) | ||||||||
| GC | CBX3 | CBX3↑ | BI; IHC | (91) | ||||||||
| GC | CBX4 | CBX4↑ | BI | (92) | ||||||||
| GC | CBX1/2/3/4/5 | CBX7 | CBX3/8↑: OS↑ | BI | (93) | |||||||
| GC | CBX1/2/3/4/5/6 | CBX7 | CBX1/3/4/5/6↑ CBX7↓ | BI | (94) | |||||||
| GC | CBX/1/2/3/4/5/8 | CBX7 | CBX4/5/6/7/8↑ | CBX4/5/6/7/8↑: PFS↓ PPS↓ CBX3↑: PFS↑OS↑ | BI | (95) | ||||||
| GC | CBX/1/2/3/4/5/8 | CBX7 | CBX1/5/6/8↑ CBX7↓ | CBX1/5/6/8↑ CBX7↓: PFS↓ | BI | (96) | ||||||
| GC | CBX1/2/3/4/5/8 | CBX7 | CBX1/5/6/8↑ CBX7↓ | CBX1/5/6/8↑ CBX7↓: PFS↓ | BI | (97) | ||||||
| GC | CBX2/3 | CBX6/7 | CBX3↓ CBX4/5/6/7/8↑ | BI | (98) | |||||||
| HCC | CBX1/2/3/4/5/6/7/8 | CBX1/2/3/6/8↑ CBX7↓ | CBX1↑: DFS↓ | BI | (114) | |||||||
| HCC | CBX1 | CBX1↑ | CBX1↑ | CBX1↑: vascular invasion↑ | BI; IHC; WB; qPCR | (115) | ||||||
| HCC | CBX3 | CBX3↑ | CBX3↑ | BI; IHC; WB; qPCR | (116) | |||||||
| HCC | CBX4 | CBX4↑ | CBX4↑ | CBX4↑ | CBX4↑ | CBX4↑ | CBX4↑: RFS↓ | IHC | (11) | |||
| HCC | CBX6 | CBX6↑ | CBX6↑: RFS↓ | IHC; WB; qPCR | (117) | |||||||
| HCC | CBX6 | CBX6↑ | CBX6↑ | IHC | (118) | |||||||
| HCC | CBX7 | CBX7↓ | IHC | (119) | ||||||||
| HCC | CBX8 | CBX8↑ | IHC; WB; qPCR | (120) | ||||||||
| HCC | CBX8 | CBX8↑ | IHC; WB; qPCR | (121) | ||||||||
| HCC | CBX1/3/4/5/6/7/8 | CBX3↑ | CBX1/2/3/6/8↑ | BI | (122) | |||||||
| PAAD | CBX1/3/5/8 | CBX1/5/6/7↑ | CBX3↑ CBX2/6/7/8↓ | BI | (99) | |||||||
| PAAD | CBX7 | CBX7↓ | IHC | (109) | ||||||||
| PAAD | CBX8 | CBX8↑ | qPCR | (100) | ||||||||
| CRC | CBX3 | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑ | IHC; WB | (101) | |||||
| CRC | CBX8 | CBX8↑ | IHC | (102) | ||||||||
| CRC | CBX1/2/3/4/5/8 | CBX6/7 | CBX3↑ | CBX5/6↑ | CBX3↑: DFS↓ | BI | (103) | |||||
| CRC | CBX1/2/3/4/5/8 | CBX6/7 | CBX2↑ | CBX2↑: DFS↓ | BI | (104) | ||||||
| ccRCC | CBX3/4 | CBX1/5/6/7 | CBX3/4/8↑ CBX1/5/6/7↓ | BI | (110) | |||||||
| UBC | CBX8 | CBX8↑ | CBX8↑ | CBX8↑: RFS↓ | IHC; WB | (105) | ||||||
| OC | CBX1/2/3 | CBX1/3↑: chemoresistance↑ | CBX1/2/3↑ | CBX1/2/3↑: PFS↓ | BI | (123) | ||||||
| OC | CBX3/8 | CBX1/6/7 | CBX2/4/5/8↑ | CBX2/4/5/8↑: chemoresistance↑ | CBX1/2/3↑ | CBX1/2/3↑: PFS↓ | BI | (111) | ||||
| OC | CBX2 | CBX2↑ | BI | (124) | ||||||||
| CCA | CBX7 | CBX7↓ | CBX7↓ | CBX7↓ | CBX7↓: vascular invasion↑ | CBX7↓ | IHC | (112) | ||||
| Sarcoma | CBX1/3/4/5/6/8 | CBX1/3/5↑ CBX7↓ | CBX2↑ CBX6/7↓: RFS↓ | BI | (106) | |||||||
| Osteosarcoma | CBX3 | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑ | CBX3↑: DFS↓ | BI | (107) | ||||
| Osteosarcoma | CBX4 | CBX4↑ | qPCR | (108) | ||||||||
| SKCM | CBX2/3/5/6 | CBX7/8 | CBX5↑ CBX7↓ | BI | (113) | |||||||
CBX, chromobox; ↑, upregulation; ↓, downregulation; TSCC, tongue squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma; BC, breast cancer; NSCLC, non-small cell lung cancer; LUAD, lung adenocarcinoma; EC, esophageal cancer; GC, gastric cancer; HCC, hepatocellular carcinoma; PAAD, pancreatic adenocarcinoma; CRC, colorectal cancer; ccRCC, clear cell renal cell carcinoma; UBC, urinary bladder cancer; OC, ovarian cancer; CCA, cervical carcinoma; SKCM, skin cutaneous melanoma; IDH, isocitrate dehydrogenase; HER-2, human epidermal growth factor receptor-2; EGFR, epidermal growth factor receptor; OS, overall survival; RFS, relapse-free survival; DFS, disease-free survival; PFS, progression-free survival; PPS, post-progression survival; DMFS, distant metastasis-free survival; DSS, disease-specific survival; BI, bioinformatics; WB, western blot; qPCR, quantitative PCR; IHC, immunohistochemistry.