Table VIII.
CBXs regulating malignant phenotype changes in tumors through PPIs.
| Cancer type | Malignant phenotype changes | PPIs | (Refs.) |
|---|---|---|---|
| HCC | Proliferation; migration | CBX1-HMGA2 | (115) |
| PCa | Proliferation; malignant; progression | CBX1-AR | (217) |
| NSCLC | Growth; metastases | CBX2-EZH2 | (218) |
| seOC | Growth; metastases | CBX7-E-box | (219) |
| ESCC | Proliferation; apoptosis; radiosensitivity | CBX8-APAF1 | (13) |
| HCC | Proliferation; cell cycle | CBX8-YBX1 | (220) |
| UBC | Proliferation; migration; invasion | CBX8-KPNA2 | (221) |
CBX, chromobox; PPI, protein-protein interaction; HCC, hepatocellular carcinoma; PCa, prostate carcinoma; NSCLC, non-small cell lung cancer; seOC, secondary epithelial ovarian cancer; ESCC, esophageal squamous cell carcinoma; UBC, urinary bladder cancer; HMGA2, high mobility group AT-hook 2; AR, androgen receptor; EZH2, enhancer of zeste homolog 2; APAF1, apoptotic peptidase activating factor 1; YBX1, Y-Box binding protein 1; KPNA2, karyopherin subunit alpha 2.