Table 2.
Vital signs and blood simple tests.
| Time after MCA occlusion (day) | Before operation (baseline) | 1 | 3 | 7 | 14 | 21 | 28 |
|---|---|---|---|---|---|---|---|
| Physiological parameters: | |||||||
| W (kg) | 10.6±1.0 | 10.4±0.8 | 10.0±0.8 | 10.0±0.9 | 10.0±1.2 | 9.5±0.9 | 9.6±0.8 |
| T(°C) | 38.4±0.3 | 36.1±1.3 | 36.8±0.3 | 37.7±0.8 | 36.9±0.8 | 37.3±0.5 | 38.2±1.2 |
| HR (beats/min) | 123.0±7.2 | 150.3±56.9 | 198.7±8.6 | 178.3±23.5 | 145.0±49.6 | 189.7±12.3 | 157.0±63.9 |
| R (beats/min) | 32.7±3.1 | 29.0±14.9 | 35.3±5.0 | 41.0±1.7 | 33.3±2.9 | 30.0±7.0 | 33.0±3.0 |
| Routine blood test: | |||||||
| WBC (10^9/L) | 8.7±3.0 | 15.2±5.0 | 14.6±2.3 | 13.5±4.3 | 11.1±4.8 | 8.7±2.2 | 9.0±2.0 |
| HGB (g/L) | 123.3±9.0 | 135.7±13.2 | 121.7±7.1 | 119.7±8.6 | 107.7±7.4 | 114.0±11.3 | 121.7±9.6 |
| PLT (10^9/L) | 334.0±55.1 | 388.3±73.5 | 402.3±65.0 | 548.7±158.2 | 497.3±101.7 | 563.3±151.9 | 387.0±100.5 |
| Electrolyte and glucose test: | |||||||
| K +(mmol/L) | 4.0±0.2 | 3.9±0.7 | 4.3±0.4 | 4.6±0.1 | 4.7±0.9 | 4.4±0.7 | 4.5±0.6 |
| Na+(mmol/L) | 149.2±1.8 | 150.2±1.6 | 154.9±4.8 | 151.8±3.7 | 146.5±1.9 | 147.5±1.7 | 148.7±1.8 |
| Cl -(mmol/L) | 109.3±1.5 | 106.0±2.9 | 108.9±6.9 | 106.4±4.8 | 105.8±0.4 | 104.2±1.8 | 105.4±2.4 |
| Glu(mmol/L) | 4.3±0.3 | 3.3±0.9 | 3.8±1.0 | 3.1±0.6 | 3.2±0.5 | 3.1±0.2 | 3.2±0.5 |
| Coagulation function test: | |||||||
| PT (s) | 8.7±0.3 | 9.2±0.4 | 8.7±0.4 | 8.5±0.6 | 9.3±1.0 | 8.2±0.3 | 8.4±0.2 |
| APTT (s) | 19.2±1.6 | 19.6±0.6 | 16.9±0.6 | 19.2±2.4 | 23.4±2.1 | 21.6±0.4 | 21.3±0.7 |
| TT (s) | 22.1±0.6 | 21.2±0.8 | 22.0±1.8 | 22.0±0.5 | 23.8±2.5 | 21.9±0.8 | 22.0±0.7 |
| FIB(g/L) | 2.8±1.0 | 3.3±0.7 | 6.0±0.5** | 4.4±1.5 | 3.0±0.1 | 2.5±0.1 | 2.6±0.3 |
| Liver function test: | |||||||
| ALT(U/L) | 55.5±22.6 | 149.2±11.5*** | 231.6±17.2*** | 162.3±30.3*** | 54.2±6.3 | 39.5±1.0 | 47.8±18.3 |
| AST(U/L) | 38.2±13.5 | 400.7±128.8*** | 408.0±82.5*** | 109.9±18.6 | 54.8±8.5 | 48.6±9.7 | 46.4±14.1 |
| CREA (umol/L) | 104.9±19.7 | 133.0±67.5 | 114.4±39.2 | 97.4±18.5 | 88.8±20.8 | 84.9±12.5 | 93.0±12.4 |
| ALB(g/L) | 38.2±1.0 | 38.8±3.1 | 35.1±2.2 | 35.8±1.0 | 35.9±2.7 | 38.9±1.6 | 39.1±1.9 |
Values are the mean ± SD obtained from three monkeys; statistically significant compared to baseline (before operation). One-way ANOVA.
*
P<0.05,
**
P< 0.01,
***
P< 0.001. Unmarked means no statistical difference. W, weight; T, body temperature; HR, heart rate; R, respiratory rate; WBC, white blood cell; HGB, hemoglobin; PLT: platelets; Glu, glucose; PT, prothrombin time; APTT, activated partial thromboplastin time; TT, thrombin time; FIB, fibrinogen; ALT, alanine transaminase; AST, aspartate transaminase; ALB, albumin; CREA, creatinine.