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. 2023 Feb 1;14(1):184–203. doi: 10.14336/AD.2022.0626

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copyright: © 2022 Su et al.

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Figure 8. — Microglial cells have phagocytosed LF. (A) Autofluorescence of a retinal cryosection five days after subretinal injection of LF. Aggregates of autofluorescent material in the subretinal space are clearly visible. (B) The same site of the sample, after immunostaining against CD11b using a red fluorescent dye. Co-localisation of LF autofluorescence and CD11b can be clearly seen. (C) Green LF autofluorescence can be seen in microglial cells labelled against Iba1 in the subretinal space 14 days after subretinal injection of LF. (D) More examples of Iba1-positive microglial cells in the subretinal space 14 days after LF injection. Nuclei stained with DAPI on top of the images belong to the outer nuclear layer. We checked cryosections of eyes of 5 animals for each time point, and typical results are shown.