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. 2023 Feb 1;14(1):184–203. doi: 10.14336/AD.2022.0626

Figure 9.

Figure 9.

Changes of outer retina morphology on ultrastructural level. (A) Typical appearance of outer ocular structures of an untreated mouse eye in transmission electron microscopy including photoreceptor outer segments (PR OS), RPE cells and the choroid (Ch) with its densely packed melanocytes. Black arrowheads point to the basal labyrinth of the RPE cells, and white arrowheads to Bruch’s membrane in every image. Appearance of a corresponding area 7 days (B) or 21 days (C) after subretinal injection of PBS. Photoreceptor outer segments, RPE cells with the basal labyrinth and Bruch’s membrane look quite normal. (D) Seven days after subretinal injection of LF, many LF particles can be seen on the apical side of the RPE cells. (E) Structure of RPE cells shows signs of beginning deterioration 21 days after injection, with asterisks indicating vacuoles. Arrows point to some fragments of PR OS, and a lot of poorly defined debris can be seen on top of the RPE cells. Some RPE cells have almost degenerated 21 days after injection of LF (F). Ch: choroid. Scale bars: 5 µm in all images.