Fig. 4.

Locations of adaptive amino acids in the structure of protein. (A) Structure of VACV D13L-encoded protein (PDB: 2ygc) A chain, with J1 and J2 domains in steel blue and teal respectively, and the head domain in pink. Selected amino acids are shown as red spheres. (B) Structure of VACV D13L-encoded protein J1 domain. Selected amino acids are shown as red spheres. (C) Structure predicted by Alphafold2 for the MPXV B5R-encoded protein, including four SCR-like domains in teal and a stalk in steel blue. Adaptive amino acids are represented as red spheres. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)