FIGURE 3.

Interactions of mature dendritic cells enriched in immunoregulatory molecules (mregDCs) with other lymphocytes in tumour immune microenvironment. Multiple ligand genes are expressed by mregDCs, allowing them to interact with a wide variety of T cells. In this figure, the pink area represents the antitumour immunity induced by mregDCs, and the blue denotes their immunomodulatory function. The immunosuppressive function of mregDCs can result in T‐cell exhaustion by immune checkpoint molecules and recruit regulatory T cells (Tregs) through secreted chemokines forming an immunosuppressive microenvironment. Maturation of DCs presenting the mregDC program and antigen‐presenting functions in turn confer antitumour capacity, stimulating B cell and T lymphocyte activation through the presentation of tumour antigens and expression of immune costimulatory molecules. mregDCs play a crucial and irreplaceable role in the immune microenvironment. Created with BioRender.com.