TABLE 2.

Mature dendritic cells enriched in immunoregulatory molecules (mregDCs) in the inflammatory microenvironment in single‐cell transcriptome research.

Disease	Methodology	Samples	Species	Key markers	Name	Ref.
Acute sterile skin inflammation	scRNA‐seq	Healthy skin and sterile skin wounds	Human	CD83, CCL22, CCR7, HLA‐DPA1 and LAMP3	BDCA‐2+ CD123 int DCs	41
Chronic inflammatory skin diseases	Smart‐seq2	Healthy skin and atopic dermatitis and psoriasis lesions	Human	CCL17, LAMP3, BIRC3, CD200, IL‐15, IL‐32	mregDCs	46
Atopic dermatitis	10× genomics	Lesional and nonlesional skin	Human	CCR7, CCL22, LAMP3, BIRC3	LAMP3+CCR7+ DCs	48
Polymicrobial sepsis	10× genomics	Bone marrow, peripheral blood and spleen	Mouse	Cd86, Cd274, Marcks, Il4ra, Ccr7	mregDCs	49
Atherosclerosis	Public datasets	Mouse aortic leucocyte	Mouse	Fscn1, Ccr7	mregDCs	100
–	10× genomics	Healthy corneal tissue	Human	LAMP3, BIRC3	mregDCs	45
Oropharyngeal diseases	10× genomics	Tumour tissues and nonmalignant inflamed tissues	Human	LAMP3, CCR7, CCL19, CSF2RA	mregDCs	28

Abbreviations: CCL, CC chemokine ligand; CCR, CC chemokine receptor; IL, interleukin; LAMP3, lysosomal‐associated membrane protein 3; scRNA‐seq, single‐cell RNA sequencing.