Table 2.

Principal substrates of ADAMs in the field of gastroenterology.

ADAM	Other names	Substrates
ADAM9	MDC9, meltrin γ	ADAM10, EGF, HB-EGF, MICA, TNF-α
ADAM10	MADM	EGF, HB-EGF, IL-6R, MICA, Notch
ADAM17	TACE	EGF, HB-EGF, ICAM-1, IL-6R, MICA, MICB, Notch, TGF-α, TNF-α

The critical immune system-related molecules, which are principal substrates of ADAMs in the field of gastroenterology, are shown.

MDC9 metalloproteinase/disintegrin/cysteine-rich 9, MADM Mammalian disintegrin-metalloprotease, TACE tumor necrosis factor-α converting enzyme.