FIGURE 6.

Slow wave activity in the Parkinsonian condition. (A) Network activity when known parameter changes following dopamine depletion (Table 3) were applied to the parameter setting reproducing the normal SWA shown in Figure 4A. The adjustment of striatal firing rates was not applied yet, (i.e., s _i, s _d = 1.0, 1.0). (B) Dependence on scaling parameters, s _i and s _d, of STN‐GPe firing rates. Based on the experimentally observed firing rates of STN and GPe neurons, effective firing rates of iSPN and dSPN for striato‐pallidal inputs were explored by introducing the scaling parameters. (C) Resultant network activity during SWA for the Parkinsonian condition after adjustment of model parameters. Spike raster displays, membrane potential time courses, and phases of spikes to SWA, similar to Figure 4. In addition to the parameter changes summarized in Table 3, the scaling parameters of striatal firing rates, s _i and s _d, were set to 0.6 and 1.0.