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. 2022 Aug 24;478(3):637–649. doi: 10.1007/s11010-022-04535-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Bioinformatic analysis of exosome encapsulated miRs. A Procedure for collecting synovial fluid from knee of human volunteers. B Western blot analysis of CD63 and TAPA-1 in exosomes like vesicles. C Transmission electron microscopic morphological analysis of exosomes like vesicles. D Heatmap showing expression of miRs in synovial fluid exosomes of OA subjects. E Annotations of KEGG pathway analysis showing various pathways