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(a) Box-and-Whisker plot of doxorubicin (DOX) concentration in the tumors of KPC mice treated with 15 mg DOX/kg low-temperature-sensitive liposomal doxorubicin (LTSL-DOX) and nonliposomal doxorubicin (DOX), with and without the application of MR-HIFU. *Denotes significance at the p < 0.05 level. (b) Median doxorubicin concentration ([interquartile range] measured in pancreatic tumors following different treatment regimens (n = 4 in each group; Farr et al., 2018)
