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. 2023 Feb 17;14:21. doi: 10.1007/s12672-023-00614-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Schematic diagram of the detection of early colorectal tumorigenesis based on STK1p combined with appropriate imaging. ROS✸: Reactive oxygen species from metabolism, inflammation, radiation, pollution, etc.; *Elevated STK1p: the STK1p value significantly increased (P < 0.0001) in the following manner: healthy mucosa (tumor-free) < enlarged polyps < dysplasia < colorectal carcinoma (CRC, TNM stage I-III) [28]. The text is explained in reference no 30