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. 2023 Feb 17;13:2858. doi: 10.1038/s41598-023-29958-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of immunohistochemical staining of 5-hmC. Strong nuclear signals of 5-hmC in the NC tissues (low-power field: a, high-power field: b) and decreased nuclear expression in CRC tissues (low-power field: c, high-power field: d). Quantitative analysis of nuclear staining intensity of 5-hmC with H-scores showed a decrease in the CRC tissues, compared to that in the NC tissues (p < 0.01, e); however, no difference was detected between Ob-CRC and nOb-CRC in both NC tissues (p = 0.95, f) and CRC tissues (p = 0.95, g). The H-scores for each case were calculated from the mean scores of three individual sections. **p < 0.01; NS no significant. NC adjacent noncancerous, CRC colorectal cancer, 5-hmC 5-hydroxymethylcytosine, Ob-CRC obese patients with colorectal cancer, nOb-CRC non-obese patients with colorectal cancer.