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. 2023 Feb 17;13:2858. doi: 10.1038/s41598-023-29958-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative determination of 5-hmC with ELISA using DNA isolated from FFPE tissues. Compared to the NC tissue, CRC tissue showed a decrease in 5-hmC as well as H-scores (p < 0.01, a). There was no difference in 5-hmC levels between the nOb-CRC and Ob-CRC groups in NC tissues (p = 0.46, b); however, there was a significant decrease in CRC tissues in the Ob-CRC group (p = 0.03, c). *p < 0.05; **p < 0.01; NS, no significant, FFPE formalin-fixed paraffin-embedded, NC the adjacent noncancerous, CRC colorectal cancer, 5-hmC 5-hydroxymethylcytosine, Ob-CRC obese patients with colorectal cancer, nOb-CRC non-obese patients with colorectal cancer.