Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 17;13:2858. doi: 10.1038/s41598-023-29958-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of metabolic factors on the proliferation and TET2 expression of human colorectal cancer cells. Treatment with 50 mM glucose-stimulated proliferation (a) and significantly decreased the expression of TET2 mRNA (b) in both HT-29 (0.71-fold, p = 0.03) and HCT116 (0.71-fold, p = 0.04) cells. Similarly, treatment with 100 nM insulin-stimulated proliferation (c) and significantly decreased the expression of TET2 mRNA (d) in both HT29 (0.47-fold, p < 0.01) and HCT116 (0.62-fold, p < 0.01). Treatment with 250 µM PA induced proliferation, while that with 250 µM OA did not induce any changes, in both cell lines (e), no significant alteration in the expression of TETs in either fatty acid treatments (f). *p < 0.05; **p < 0.01; NS no significant. TET ten-eleven translocation, Ctrl control, PA palmitic acid, OA oleic acid, ACTB β-actin.