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. 2022 Dec 23;128(3):413–418. doi: 10.1038/s41416-022-02109-6

Fig. 1. Schematic representation of a functional blood vessel and its surrounding cells.

Fig. 1

Cells that are closest to the blood vessel are richly nourished with oxygen and other nutrients and therefore proliferate rapidly. Cells that are farther away are nutrient-deprived and may become hypoxic and have an acidic microenvironment; they tend to proliferate slowly. Modified from Tan et al. [10]. ECM extracellular matrix.