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. 2022 Dec 23;128(3):413–418. doi: 10.1038/s41416-022-02109-6

Fig. 5. Inhibition of Autophagy can increase the effectiveness of anticancer drugs.

Fig. 5

a Growth curves of PC3 prostate cancer xenografts following treatment with docetaxel (DOC), pantoprazole (PTP), or both drugs. b Staining of γH2AX (a marker of DNA damage) as a function of distance from the nearest tumour blood vessel at 10 min after treatment of PC3 xenografts with saline, docetaxel, pantoprazole or both drugs. Note that PTP, an inhibitor of autophagy, has no effect alone but augments the activity of docetaxel. Adapted from Tan et al. [37].