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. 2023 Feb 17;6:189. doi: 10.1038/s42003-023-04565-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Two heart associated modules, black and turquoise, that significantly enriched three of four CHD gene sets are shown. Hub CNV-lncRNAs and CHD genes in black (a) and turquoise (b) coexpression modules are listed (Supplementary Data 1 and 5). Hub CNV-lncRNAs are highlighted with red edge. Subsets of CHD genes are indicated in different colors. Sizes of the nodes represent gene module membership value (MM) in corresponding module (Supplementary Data 5). Hypergeometric test was used to calculate statistical significance for the enrichment of coexpressed protein coding genes in black (c) and turquoise (d) module against four CHD gene sets. CHD gene sets are indicated in different colors. Significant enrichment (PH < 0.05, PH represents hypergeometric P value) was shown with the PH value in red font. Protein coding genes that went for WGCNA (n = 19,957) were used as the background gene list. e Cardiac development related pathways in the black and turquoise modules (Supplementary Data 2). Horizontal axis represents GO terms. The colors of the dots indicate different modules. The size of the dots represents gene counts of each module involved in corresponding GO terms. Values of −log₁₀(P_adj) are shown on the x axis. The red dashed line indicates P_adj of 0.05.