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. 2022 Dec 8;128(4):691–701. doi: 10.1038/s41416-022-02074-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MDS-L and MOLM-13 cells were treated with DAC (0.8 and 1.5 μM, respectively), ATRA (4 and 2 μM, respectively), or both drugs in combination for 24 h. Immunofluorescence (a) and immunoblotting analysis (b) showed that DAC treatment induced Nrf2 translocation into the nucleus. Co-treatment with DAC and ATRA did not block the translocation triggered by DAC. Compared with the Ctrl, treatment with DAC alone significantly increased the mRNA (c) and protein (d) expression levels of NQO1, DUSP1, GPX2, and FTH in MDS-L and MOLM-13 cells. At the same time, the combination of DAC and ATRA markedly reversed the upregulated expression caused by DAC.