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. 2022 Dec 8;128(4):691–701. doi: 10.1038/s41416-022-02074-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Transcriptional levels of RARα in sh1 and sh2 cells were significantly reduced compared with the shCtrl. Immunoblots with anti‐RARα and anti‐GAPDH antibodies showed that RARα protein expression was markedly decreased in sh1 and sh2 cells. Flow cytometry staining with annexin V-APC (b) and western blotting results (c) showed that RARα KD reversed the apoptosis induced by the combined treatment, but not that induced by DAC alone. MDS-L and MOLM-13 cells were treated with DAC (0.8 and 1.5 μM, respectively) or DAC and ATRA (4 and 2 μM, respectively) for 48 h.