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. 2022 Dec 8;128(4):691–701. doi: 10.1038/s41416-022-02074-0

Fig. 5. RARα-Nrf2 complex activation after combined treatment with DAC and ATRA.

Fig. 5

Immunoprecipitation and immunoblotting indicated the formation of a RARα-Nrf2 complex in MDS-L and MOLM-13 cells treated with DAC, as a single agent or combined with ATRA. The expression level of HDAC1 binding to the complex was reduced after the combination treatment.