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. 2022 Dec 8;128(4):691–701. doi: 10.1038/s41416-022-02074-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Compared with the Ctrl and mono-drug group, the combined treatment with DAC and ATRA significantly reduced the tumour burden in a murine model. b The leukaemia burden was lowest in the COM group on Day 17, as indicated by the photon intensity (P < 0.05). c Co-treatment with DAC and ATRA significantly improved the survival time in the murine model (P < 0.05). d HE and IHC staining of the murine spleens showed that the combined DAC and ATRA regimen reduced malignant cell infiltration in vivo. Red arrow, MOLM-13-Luc cells; green arrow, murine spleen cells.