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. 2022 Dec 8;128(4):691–701. doi: 10.1038/s41416-022-02074-0

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Treatment with DAC alone induced ROS generation and activated the Nrf2-ARE antioxidant response. Co-treatment with DAC and ATRA reduced the level of HDAC1 binding to the RARα-Nrf2 complex, prevented the activation of Nrf2 by DAC alone, and blocked transcriptional activation of Nrf2 downstream antioxidant genes.