Table 1.
Percent total weight loss after RYGB or VSG in humans and diet-induced obese rodents. For human studies, only representative RCTs in male and female patients with obesity, lasting at least 5 years, and reporting total percent weight loss are included. Standard deviation or 95% confidence intervals are reported depending on availability. For rodents, only studies in diet-induced (either 45% or 60% high-fat diet exposure for various time periods) obese male rats or mice and lasting at least 8 weeks are included. Percent weight loss at specific time points in rodent studies was extrapolated from published body weight curves and are estimates only. For some rodent studies difference of final body weight after surgery vs sham surgery is indicated in square brackets. Numbers in parentheses depict the number of subjects. Note that in rodent studies, different starting body weights, housing methods (e.g. single housing), immediate postsurgical regimens, and experimental loads (e.g. frequent blood sampling) may have influenced surgery-induced weight loss. Based on average life expectancy, 2 and 10 weeks of rodent life can be considered as the approximate equivalent of 1 and 5 years of human life.
| RYGB | VSG | ||||
|---|---|---|---|---|---|
| Human | 1 year | 5–12 years | 1 year | 5–10 years | |
| Schauer et al. [6] | −29.4 ± 8.9 (50) −10.2 BMI |
−23.2 ± 9.6 (50) 5 y −8.1 BMI |
−25.1 ± 8.5 (50) −8.9 BMI |
−18.6 ± 7.5 (50) −6.7 BMI 5 y |
|
| Salminen et al. [279] | −30.6 (120) | −26.9 (120) 5 y | −27.3 (120) | −22.9 (120) 5 y | |
| Arterburn et al. [3] | −31.2 (32,208) | −25.5 (32,208) 5 y | −25.2 (29,693) | −18.8 (29,693) 5 y |
|
| Arterburn et al. [280] | −28.4 (17,258) | −21.7 (17,258) 5 y | −23.0 (13,900) | −16.0 (13,900) 10 y |
|
| Courcoulas et al. [281] | −33.8 [28.3–39.8] (50) | −28.4 [27.6–29.2] (50) 10 y | |||
| Adams et al. [15] | −26.9 [-28.2 to −25.6] (387) 12 y | ||||
| Rat | 2 weeks | 10–20 weeks | 2 weeks | 10–20 weeks | |
| Stylopoulos et al. [282] | −19.9 (15) | −12.0 (15) 20w [-21.2] | Stefater et al. [119] | −19.0 (9) | +19.8 (9) 17w [-9.8] |
| Zheng et al. [27] | −18.2 (13) | −16.5 (10) 20w [-24.5] | Alvarez et al. [283] | −15.0 (13) | ±0.0 (12) 10w [-10.0] |
| Abegg et al. [284] | −20.5 (7) | −10.2 (7) 10w [-34.2] | Basso et al. [285] | −14.3 (21) | +18.0 (21) 10w [-1.3] |
| Thanos et al. [286] | −15.0 (11) | −19.4 (11) 10w [-24.0} | Mumphrey et al. [37] | −18.5 (8) | −6.0 (8) 10w [-13.6] |
| Mouse | |||||
| Hatoum et al. [259] | −34.6 (5) | −17.9 (5) 9w [-34.5] | Ryan et al. [243] | −26.3 (8) | ±0.0 (8) 10w [-11.6] |
| Uchida et al. [287] | −28.3 (16) | −21.7 (16) 5w [-24.5] | Ding et al. [288] | −26.6 (9) | −14.9 (9) 10w [-21.2] |
| Flynn et al. [289] | −28.0 (7) | −29.0 (7) 8w [-41.3] | Du et al. [290] | −24.5 (5) | −10.2 (5) 10w [-20.0] |
| Stevenson et al. [8] | −24.4 (6) | −25.6 (6) 10w [-41.6] | −21.7 (6) | −15.2 (6) 10w [+5.0] | |
| Hao et al. [7] | −22.5 (9) | −22.5 (9) 10w [-39.8] | −5.0 (9) | +10.5 (9) 10w [-18.3] | |