Table 1.
Top Canonical Pathways differentially expressed in the EDL of ERRα/γ dmKO mice and their Rank and P-value in all ERR KO lines.
| Canonical pathways | ERRα/γ dmKO |
ERRα mKO |
ERRβ/γ dmKO |
|||
|---|---|---|---|---|---|---|
| Rank | P-Value | Rank | P-Value | Rank | P-Value | |
| Oxidative phosphorylation | #1 | 5.4E-40 | #1 | 9.2E-08 | #289 | 1 |
| Mitochondrial dysfunction | #2 | 7.1E-40 | #2 | 2.9E-07 | #209 | 1 |
| Sirtuin Signaling Pathway | #3 | 7.4E-14 | #26 | 2.3E-02 | #176 | 0.5 |
| EIF2 Signaling | #4 | 2.2E-12 | #394 | 1 | NA | – |
| TCA Cycle | #5 | 1.5E-11 | #421 | 1 | NA | – |
| Valine Degradation | #6 | 4.3E-08 | NA | – | #120 | 0.3 |
| Leucine Degradation | #7 | 4.8E-06 | NA | – | NA | – |
| Isoleucine Degradation | #8 | 5.1E-05 | NA | – | #23 | 4.3E-02 |
NA, non-applicable; these pathways were not identified as regulated in ERRα mKO or ERRβ/γ dmKO EDL muscles. For ERRα/γ dmKO EDL, only pathways with p < 1 × 10E-04 are shown; for ERRα mKO EDL, only the two pathways shown here had P-Value <1 × 10E-04; For ERR β/γ dmKO EDL, only one pathway was decreased with p < 1 × 10E-4 (Agranulocyte Adhesion and Diapedesis, P = 5.9E-05).