Table 2.
Top Canonical Pathways differentially expressed in the soleus of ERRα/γ dmKO mice and their Rank and P-value in all ERR KO lines.
| Canonical pathways | ERRα/γ dmKO |
ERRα mKO |
ERRβ/γ dmKO |
|||
|---|---|---|---|---|---|---|
| Rank | P-Value | Rank | P-Value | Rank | P-Value | |
| Mitochondrial dysfunction | #1 | 2.4E-33 | #354 | 1 | #242 | 1 |
| Oxidative phosphorylation | #2 | 1.0E-32 | #404 | 1 | #398 | 1 |
| Sirtuin Signaling Pathway | #3 | 5.8E-12 | #312 | 0.5 | #447 | 1 |
| Valine Degradation | #4 | 3.4E-09 | NA | – | #2 | 8.3E-08 |
| TCA Cycle | #5 | 4.2E-09 | NA | – | #162 | 0.4 |
| Fatty Acid Oxidation | #6 | 4.9E-06 | NA | – | #1 | 4.6E-08 |
| Isoleucine Degradation | #7 | 9.5E-06 | NA | – | #5 | 3.6E-06 |
| Glycolysis | #8 | 5.1E-05 | #124 | 0.1 | #122 | 0.2 |
| Acetyl-CoA Biosynthesis | #9 | 5.8E-05 | NA | – | #134 | 0.3 |
NA, non-applicable; these pathways were not identified as regulated in ERRα mKO or ERRβ/γ dmKO soleus. For ERRα/γ dmKO soleus, only pathways with p < 1 × 10E-04 are shown. For ERRα mKO soleus, only one pathway was decreased with p < 1 × 10E-4 (TR/RXR Activation, P = 6.0E-05). Pathways significantly deregulated in ERR β/γ dmKO soleus are shown in Table 3.