Table 3.

Clinical outcomes and hemodynamic performance at 5 years of follow-up for patients who underwent aortic valve replacement in the propensity score-matched cohort

	Pledgets (n = 397)	No pledgets (n = 397)	P value∗
Composite endpoint (thromboembolism, endocarditis, and major PVL)	11.7% (8.7%-15.7%) (n = 41)	9.8% (7.1%-13.4%) (n = 36)	.51
Thromboembolism	5.9% (3.9%-8.9%) (n = 22)	6.1% (4.1%-9.3%) (n = 22)	.95
Endocarditis	6.4% (4.1%-9.9%) (n = 20)	4.2% (2.5%-6.9%) (n = 15)	.35
Major PVL	0.3% (0.0%-1.8%) (n = 1)	0.0% (NA) (n = 0)	.32
All PVL	1.1% (0.4%-2.8%) (n = 4)	1.5% (0.5%-4.0%) (n = 4)	.96
All-cause mortality	13.3% (10.0%-17.6%) (n = 45)	10.5% (7.7%-14.2%) (n = 37)	.30
Cardiac-related mortality	6.8% (4.4%-10.3%) (n = 22)	4.2% (2.5%-7.1%) (n = 14)	.15
Valve-related mortality	2.2% (1.1%-4.4%) (n = 8)	0.5% (0.1%-2.1%) (n = 2)	.06
Reintervention	3.1% (1.7%-5.5%) (n = 11)	3.9% (2.2%-6.7%) (n = 13)	.74
Explant	3.1% (1.7%-5.5%) (n = 11)	3.2% (1.7%-5.7%) (n = 11)	.95
Permanent pacemaker implantation	5.6% (3.7%-8.5%) (n = 21)	6.9% (4.6%-10.1%) (n = 25)	.55
Mean pressure gradient, mm Hg	12.3 ± 4.4	12.3 ± 4.0	.93
Peak pressure gradient, mm Hg	22.0 ± 7.4	21.9 ± 7.4	.93
EOA, cm2	1.35 (0.72-2.87)	1.44 (0.79-2.58)	.045
EOAi, cm2/m2	0.69 (0.38-1.31)	0.73 (0.41-1.31)	.06
Prosthesis-patient mismatch			.07
None	40 (31.7%)	44 (32.6%)
Moderate	46 (36.5%)	64 (47.4%)
Severe	40 (31.7%)	27 (2.0%)

Clinical outcomes are reported as 5-year Kaplan–Meier event rates, including 95% CI. Hemodynamic performance is presented either as mean ± SD or median (interquartile range). PVL, Paravalvular leak; NA, not available; EOA, effective orifice area; EOAi, effective orifice area indexed according to body surface area.

^∗P value from log rank test for all clinical outcomes and from independent samples t test, Mann–Whitney U test, or χ² test for echocardiographic data.