Table 1.
Iron overload and ferritin kinetics following 1.2 years (median) of chelation in thalassemic patients (n = 136).
| Baseline Median (range/SD) | Follow-up Median (range/SD) | p-valuea | |
|---|---|---|---|
|
Myocardium (Fe mg/g) |
0.86 (0.22–12.8/1.95) | 0.77 (0.34-17.2/2.0) | 0.024 |
|
Ferritin (ng/ml) |
2033 (59–14123/2347) | 1735 (180-11925/2148) | 0.001 |
|
LIC (Fe mg/g) |
8.4 (1.0–51.0/9.4) | 8.14 (1.1-25.0/6.0) | 0.118 |
|
R2* pancreas (Hertz) |
136.0 (19–526/120) | 116.9 (19 –1000/152) | 0.512 |
SD: standard deviation; LIC: liver iron concentration.
a
Paired Wilcoxon-Mann-Whitney test